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Gene TP53
Variant R337C
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 R337C lies within the tetramerization domain of the Tp53 protein (PMID: 20978130). R337C results decreased tetramerization, loss of Tp53 transcriptional activity, decreased apoptotic response to irradiation in cell culture (PMID: 19454241, PMID: 9150393), increased colony formation compared to wild-type in the presence of an MDM2 antagonist in cell culture, and tumor growth in mouse models (PMID: 35165384).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon10 TP53 R337C

TP53 mutant TP53 inact mut TP53 R337C

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Transcript NM_000546.6
gDNA chr17:g.7670700G>A
cDNA c.1009C>T
Protein p.R337C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126112.2 chr17:g.7670700G>A c.1009C>T p.R337C RefSeq GRCh38/hg38
NM_001126112 chr17:g.7670700G>A c.1009C>T p.R337C RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7673249_7673251delCGAinsTGT c.1009_1011delCGAinsTGT p.R337C RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7673249_7673251delCGAinsTGT c.1009_1011delCGAinsTGT p.R337C RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7670700G>A c.1009C>T p.R337C RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7670700G>A c.1009C>T p.R337C RefSeq GRCh38/hg38
NM_000546 chr17:g.7670700G>A c.1009C>T p.R337C RefSeq GRCh38/hg38
NM_001126113 chr17:g.7673249_7673251delTCGinsACA c.1009_1011delCGAinsTGT p.R337C RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7670700G>A c.1009C>T p.R337C RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7670700G>A c.1009C>T p.R337C RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7670700G>A c.1009C>T p.R337C RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7670700G>A c.1009C>T p.R337C RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References