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Gene TP53
Variant R337L
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 R337L lies within the tetramerization domain of the Tp53 protein (PMID: 20978130). R337L results in reduced Tp53 tetramerization and decreased DNA binding and transactivation activity in cell culture (PMID: 19454241, PMID: 9766574).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon10 TP53 R337L

TP53 mutant TP53 inact mut TP53 R337L

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Transcript NM_000546.6
gDNA chr17:g.7670699C>A
cDNA c.1010G>T
Protein p.R337L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126112.2 chr17:g.7670699C>A c.1010G>T p.R337L RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7673250C>A c.1010G>T p.R337L RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7670699C>A c.1010G>T p.R337L RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7670699C>A c.1010G>T p.R337L RefSeq GRCh38/hg38
NM_000546 chr17:g.7670699C>A c.1010G>T p.R337L RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7670699C>A c.1010G>T p.R337L RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7670699C>A c.1010G>T p.R337L RefSeq GRCh38/hg38
NM_001126112 chr17:g.7670699C>A c.1010G>T p.R337L RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7673250C>A c.1010G>T p.R337L RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7670699C>A c.1010G>T p.R337L RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7670699C>A c.1010G>T p.R337L RefSeq GRCh38/hg38
NM_001126113 chr17:g.7673250C>A c.1010G>T p.R337L RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References