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Gene TP53
Variant R337P
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 R337P lies within the tetramerization domain of the Tp53 protein (PMID: 20978130). R337P results in decreased Tp53 tetramerization and transactivation activity and increased colony formation in cell culture (PMID: 19454241, PMID: 29955864).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon10 TP53 R337P

TP53 mutant TP53 inact mut TP53 R337P

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Transcript NM_000546.6
gDNA chr17:g.7670699C>G
cDNA c.1010G>C
Protein p.R337P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113 chr17:g.7673250C>G c.1010G>C p.R337P RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7670699C>G c.1010G>C p.R337P RefSeq GRCh38/hg38
NM_000546 chr17:g.7670699C>G c.1010G>C p.R337P RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7670699C>G c.1010G>C p.R337P RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7670699C>G c.1010G>C p.R337P RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7670699C>G c.1010G>C p.R337P RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7670699C>G c.1010G>C p.R337P RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7670699C>G c.1010G>C p.R337P RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7673250C>G c.1010G>C p.R337P RefSeq GRCh38/hg38
NM_001126112 chr17:g.7670699C>G c.1010G>C p.R337P RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7670699C>G c.1010G>C p.R337P RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7673250C>G c.1010G>C p.R337P RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References