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Gene TP53
Variant F341C
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 F341C lies within the tetramerization domain of the Tp53 protein (PMID: 20978130). F341C results in decreased Tp53 tetramerization in cell culture (PMID: 19454241) and in yeast (PMID: 16007150), and reduced Tp53 transcriptional activity in a reporter assay (PMID: 19454241), and therefore, is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon10 TP53 F341C

TP53 mutant TP53 inact mut TP53 F341C

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Transcript NM_000546.6
gDNA chr17:g.7670687A>C
cDNA c.1022T>G
Protein p.F341C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113 chr17:g.7673238A>C c.1022T>G p.F341C RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7673238A>C c.1022T>G p.F341C RefSeq GRCh38/hg38
NM_001126112 chr17:g.7670687A>C c.1022T>G p.F341C RefSeq GRCh38/hg38
NM_000546 chr17:g.7670687A>C c.1022T>G p.F341C RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7670687A>C c.1022T>G p.F341C RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7670687A>C c.1022T>G p.F341C RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7670687A>C c.1022T>G p.F341C RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7670687A>C c.1022T>G p.F341C RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7670687A>C c.1022T>G p.F341C RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7670687A>C c.1022T>G p.F341C RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7670687A>C c.1022T>G p.F341C RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7673238A>C c.1022T>G p.F341C RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References