Gene Variant Detail

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Gene TP53
Variant D324A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 D324A lies within the tetramerization domain of the Tp53 protein (PMID: 20978130). D324A demonstrates increased transcription activity and tetramerization ability similar to wild-type Tp53 in yeast (PMID: 16007150), but has not been characterized in human cells and therefore, its effect on Tp53 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon9 TP53 D324A

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Transcript NM_000546.6
gDNA chr17:g.7673557T>G
cDNA c.971A>C
Protein p.D324A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.2 chr17:g.7673557T>G c.971A>C p.D324A RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7673557T>G c.971A>C p.D324A RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7673557T>G c.971A>C p.D324A RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7673557T>G c.971A>C p.D324A RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7673557T>G c.971A>C p.D324A RefSeq GRCh38/hg38
NM_001126113 chr17:g.7673557T>G c.971A>C p.D324A RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7673557T>G c.971A>C p.D324A RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7673557T>G c.971A>C p.D324A RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7673557T>G c.971A>C p.D324A RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7673557T>G c.971A>C p.D324A RefSeq GRCh38/hg38
NM_000546 chr17:g.7673557T>G c.971A>C p.D324A RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7673557T>G c.971A>C p.D324A RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7673557T>G c.971A>C p.D324A RefSeq GRCh38/hg38
NM_001126114 chr17:g.7673557T>G c.971A>C p.D324A RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7673557T>G c.971A>C p.D324A RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7673557T>G c.971A>C p.D324A RefSeq GRCh38/hg38
NM_001126112 chr17:g.7673557T>G c.971A>C p.D324A RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References