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Gene | TP53 |
Variant | T329A |
Impact List | missense |
Protein Effect | no effect |
Gene Variant Descriptions | TP53 T329A lies within the tetramerization domain of the Tp53 protein (PMID: 20978130). T329A demonstrates activity similar to wild-type TP53 including transactivation activity, suppression of the MDR-1 promoter, and cell growth inhibition (PMID: 10329187). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon9 TP53 T329A |
Transcript | NM_000546.6 |
gDNA | chr17:g.7673543T>C |
cDNA | c.985A>G |
Protein | p.T329A |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |