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Gene HRAS
Variant G12X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions HRAS G12X indicates any HRAS missense mutation that results in replacement of the glycine (G) at amino acid 12 by a different amino acid. HRAS G12 mutations are hotspot mutations that often result in decreased Hras GTPase activity, leading to activation of downstream signaling and transformation of cultured cells (PMID: 6092966, PMID: 24224811, PMID: 26985062).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS G12X

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Transcript NM_005343.4
gDNA chr11:g.534287_534289
cDNA c.34_36
Protein p.G12
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795.5 chr11:g.534287_534289 c.34_36 p.G12 RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534287_534289 c.34_36 p.G12 RefSeq GRCh38/hg38
NM_001130442 chr11:g.534287_534289 c.34_36 p.G12 RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534287_534289 c.34_36 p.G12 RefSeq GRCh38/hg38
NM_005343 chr11:g.534287_534289 c.34_36 p.G12 RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534287_534289 c.34_36 p.G12 RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534287_534289 c.34_36 p.G12 RefSeq GRCh38/hg38
NM_176795 chr11:g.534287_534289 c.34_36 p.G12 RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534287_534289 c.34_36 p.G12 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
HRAS G12X unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)