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Gene HRAS
Variant G13X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions HRAS G13X indicates any HRAS missense mutation that results in replacement of the glycine (G) at amino acid 13 by a different amino acid. HRAS G13 mutations are hotspot mutations that often result in decreased Hras GTPase activity, leading to activation of downstream signaling and transformation of cultured cells (PMID: 8430333, PMID: 21850009, PMID: 24224811, PMID: 26985062).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS G13X

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Transcript NM_005343.4
gDNA chr11:g.534284_534286
cDNA c.37_39
Protein p.G13
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795 chr11:g.534284_534286 c.37_39 p.G13 RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534284_534286 c.37_39 p.G13 RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534284_534286 c.37_39 p.G13 RefSeq GRCh38/hg38
NM_001130442 chr11:g.534284_534286 c.37_39 p.G13 RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534284_534286 c.37_39 p.G13 RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534284_534286 c.37_39 p.G13 RefSeq GRCh38/hg38
NM_005343 chr11:g.534284_534286 c.37_39 p.G13 RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534284_534286 c.37_39 p.G13 RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534284_534286 c.37_39 p.G13 RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06625320 Phase III Fluorouracil + Leucovorin + Liposomal irinotecan Fluorouracil + Leucovorin + Oxaliplatin Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Gemcitabine + Nab-paclitaxel RMC-6236 Phase 3 Study of RMC-6236 in Patients with Previously Treated Metastatic Previously Treated Metastatic Pancreatic Ductal Adenocarcinoma (PDAC) (RASolute 302) Recruiting USA 1
NCT05379985 Phase I RMC-6236 Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS Recruiting USA 0