Gene Variant Detail

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Gene HRAS
Variant Q61X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions HRAS Q61X indicates any HRAS missense mutation that results in replacement of the glutamine (Q) at amino acid 61 by a different amino acid. HRAS Q61 mutations are hotspot mutations that often result in decreased Hras GTPase activity, leading to activation of downstream signaling and transformation of cultured cells (PMID: 3510078, PMID: 26985062).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS Q61X

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Transcript NM_005343.4
gDNA chr11:g.533873_533875
cDNA c.181_183
Protein p.Q61
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795.5 chr11:g.533873_533875 c.181_183 p.Q61 RefSeq GRCh38/hg38
NM_005343 chr11:g.533873_533875 c.181_183 p.Q61 RefSeq GRCh38/hg38
NM_176795 chr11:g.533873_533875 c.181_183 p.Q61 RefSeq GRCh38/hg38
NM_005343.3 chr11:g.533873_533875 c.181_183 p.Q61 RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533873_533875 c.181_183 p.Q61 RefSeq GRCh38/hg38
NM_001130442 chr11:g.533873_533875 c.181_183 p.Q61 RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533873_533875 c.181_183 p.Q61 RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533873_533875 c.181_183 p.Q61 RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533873_533875 c.181_183 p.Q61 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05907304 Phase I LXH 254 + Trametinib A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With RAS Q61X Mutations (SEACRAFT-1) Recruiting USA | GBR | CAN | AUS 1
NCT04916236 Phase I LY3214996 + RMC-4630 Combination Therapy of RMC-4630 and LY3214996 in Metastatic KRAS Mutant Cancers (SHERPA) Unknown status NLD 0
NCT06625320 Phase III Fluorouracil + Leucovorin + Liposomal irinotecan Fluorouracil + Leucovorin + Oxaliplatin Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Gemcitabine + Nab-paclitaxel RMC-6236 Phase 3 Study of RMC-6236 in Patients with Previously Treated Metastatic Previously Treated Metastatic Pancreatic Ductal Adenocarcinoma (PDAC) (RASolute 302) Recruiting USA 1
NCT05379985 Phase I RMC-6236 Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS Recruiting USA 0