HRAS Q61X
Gene Variant Detail

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Gene HRAS
Variant Q61X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions HRAS Q61X indicates any HRAS missense mutation that results in replacement of the glutamine (Q) at amino acid 61 by a different amino acid. HRAS Q61 mutations are hotspot mutations that often result in decreased Hras GTPase activity, leading to activation of downstream signaling and transformation of cultured cells (PMID: 3510078, PMID: 26985062).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS Q61X

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Transcript NM_005343.4
gDNA chr11:g.533873_533875
cDNA c.181_183
Protein p.Q61
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795.5 chr11:g.533873_533875 c.181_183 p.Q61 RefSeq GRCh38/hg38
NM_005343.3 chr11:g.533873_533875 c.181_183 p.Q61 RefSeq GRCh38/hg38
NM_176795 chr11:g.533873_533875 c.181_183 p.Q61 RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533873_533875 c.181_183 p.Q61 RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533873_533875 c.181_183 p.Q61 RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533873_533875 c.181_183 p.Q61 RefSeq GRCh38/hg38
NM_001130442 chr11:g.533873_533875 c.181_183 p.Q61 RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533873_533875 c.181_183 p.Q61 RefSeq GRCh38/hg38
NM_005343 chr11:g.533873_533875 c.181_183 p.Q61 RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06625320 Phase III Fluorouracil + Leucovorin + Liposomal irinotecan Fluorouracil + Leucovorin + Oxaliplatin Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Gemcitabine + Nab-paclitaxel Daraxonrasib Phase 3 Study of RMC-6236 in Patients with Previously Treated Metastatic Previously Treated Metastatic Pancreatic Ductal Adenocarcinoma (PDAC) (RASolute 302) Recruiting USA | ITA | FRA | ESP | DEU 2
NCT04916236 Phase I LY3214996 + RMC-4630 Combination Therapy of RMC-4630 and LY3214996 in Metastatic KRAS Mutant Cancers (SHERPA) Terminated NLD 0
NCT05907304 Phase I LXH 254 + Trametinib A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With RAS Q61X Mutations (SEACRAFT-1) Active, not recruiting USA | GBR | CAN | AUS 1
NCT05379985 Phase I Daraxonrasib Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS Recruiting USA 0
NCT06881784 Phase III Docetaxel Daraxonrasib Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301) (RASolve 301) Recruiting USA | POL | NLD | ITA | IRL | FRA | ESP | DEU | CHE | BEL 5