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Gene TP53
Variant L323R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 L323R lies within the CARM1, HIPK1, and HIPK2-interacting regions of the Tp53 protein (UniProt.org). L323R has been identified in sequencing studies (PMID: 10225439), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon9 TP53 L323R

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Transcript NM_000546.6
gDNA chr17:g.7673560A>C
cDNA c.968T>G
Protein p.L323R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126114 chr17:g.7673560A>C c.968T>G p.L323R RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7673560A>C c.968T>G p.L323R RefSeq GRCh38/hg38
NM_001126112 chr17:g.7673560A>C c.968T>G p.L323R RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7673560A>C c.968T>G p.L323R RefSeq GRCh38/hg38
NM_001126113 chr17:g.7673560A>C c.968T>G p.L323R RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7673560A>C c.968T>G p.L323R RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7673560A>C c.968T>G p.L323R RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7673560A>C c.968T>G p.L323R RefSeq GRCh38/hg38
NM_000546 chr17:g.7673560A>C c.968T>G p.L323R RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7673560A>C c.968T>G p.L323R RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7673560A>C c.968T>G p.L323R RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7673560A>C c.968T>G p.L323R RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7673560A>C c.968T>G p.L323R RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7673560A>C c.968T>G p.L323R RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7673560A>C c.968T>G p.L323R RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7673560A>C c.968T>G p.L323R RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7673560A>C c.968T>G p.L323R RefSeq GRCh38/hg38

Filtering

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  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References