TP53 K321R
Gene Variant Detail

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Gene TP53
Variant K321R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 K321R lies within the HIPK1, CARM1, and HIPK2-interacting regions and the bipartite nuclear localization signal motif of the Tp53 protein (UniProt.org). K321R maintains acetylation in an in vitro assay (PMID: 9891054) and Daxx binding similar to the level of wild-type Tp53 in yeast (PMID: 15364927), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon9 TP53 K321R

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Transcript NM_000546.6
gDNA chr17:g.7673566T>C
cDNA c.962A>G
Protein p.K321R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546.5 chr17:g.7673566T>C c.962A>G p.K321R RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7673566T>C c.962A>G p.K321R RefSeq GRCh38/hg38
NM_001126112 chr17:g.7673566T>C c.962A>G p.K321R RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7673566T>C c.962A>G p.K321R RefSeq GRCh38/hg38
NM_001126114 chr17:g.7673566T>C c.962A>G p.K321R RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7673566T>C c.962A>G p.K321R RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7673566T>C c.962A>G p.K321R RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7673566T>C c.962A>G p.K321R RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7673566T>C c.962A>G p.K321R RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7673566T>C c.962A>G p.K321R RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7673566T>C c.962A>G p.K321R RefSeq GRCh38/hg38
NM_001126113 chr17:g.7673566T>C c.962A>G p.K321R RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7673566T>C c.962A>G p.K321R RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7673566T>C c.962A>G p.K321R RefSeq GRCh38/hg38
NM_000546 chr17:g.7673566T>C c.962A>G p.K321R RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7673566T>C c.962A>G p.K321R RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7673566T>C c.962A>G p.K321R RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References