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Gene PIK3CA
Variant E545X
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA E545X indicates any Pik3ca missense mutation that results in the replacement of the glutamic acid (E) at amino acid 545 by a different amino acid. PIK3CA E545X mutations are hotspot mutations that may result in increased Pik3ca kinase activity (PMID: 15930273).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon10 PIK3CA E545X

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Transcript NM_006218.4
gDNA chr3:g.179218303_179218305
cDNA c.1633_1635
Protein p.E545
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894 chr3:g.179218303_179218305 c.1633_1635 p.E545 RefSeq GRCh38/hg38
XM_006713658 chr3:g.179218303_179218305 c.1633_1635 p.E545 RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179218303_179218305 c.1633_1635 p.E545 RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179218303_179218305 c.1633_1635 p.E545 RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179218303_179218305 c.1633_1635 p.E545 RefSeq GRCh38/hg38
NM_006218 chr3:g.179218303_179218305 c.1633_1635 p.E545 RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179218303_179218305 c.1633_1635 p.E545 RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179218303_179218305 c.1633_1635 p.E545 RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA E545X endometrial adenocarcinoma no benefit Copanlisib Case Reports/Case Series Actionable In a Phase II (NRG-GY008) trial, Aliqopa (copanlisib) was well tolerated but demonstrated limited efficacy, resulted in progressive disease in a patient with endometrioid adenocarcinoma harboring a PIK3CA E545 mutation, and progressive disease in a patient with serous endometrial adenocarcinoma harboring a PIK3CA E545 mutation (PMID: 31934607). 31934607