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Gene TP53
Variant T377P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 T377P lies within the region of the Tp53 protein involved in repression of DNA binding and the CARM1-interacting region (UniProt.org). T377P has been identified in sequencing studies (PMID: 27023146, PMID: 35043155), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Sep 2023).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon11 TP53 T377P

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Transcript NM_000546.6
gDNA chr17:g.7669662T>G
cDNA c.1129A>C
Protein p.T377P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126112.2 chr17:g.7669662T>G c.1129A>C p.T377P RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7669662T>G c.1129A>C p.T377P RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7669662T>G c.1129A>C p.T377P RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7669662T>G c.1129A>C p.T377P RefSeq GRCh38/hg38
NM_000546 chr17:g.7669662T>G c.1129A>C p.T377P RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7669662T>G c.1129A>C p.T377P RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7669662T>G c.1129A>C p.T377P RefSeq GRCh38/hg38
NM_001126112 chr17:g.7669662T>G c.1129A>C p.T377P RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7669662T>G c.1129A>C p.T377P RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References