Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Gene | TP53 |
Variant | K292I |
Impact List | missense |
Protein Effect | gain of function - predicted |
Gene Variant Descriptions | TP53 K292I lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). K292I is predicted to confer a gain of function to the Tp53 protein, as demonstrated by increased ability to induce apoptosis in cultured cells (PMID: 15781620). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 act mut TP53 K292I TP53 mutant TP53 exon8 TP53 K292I |
Transcript | NM_000546.6 |
gDNA | chr17:g.7673745T>A |
cDNA | c.875A>T |
Protein | p.K292I |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001126114.2 | chr17:g.7673745T>A | c.875A>T | p.K292I | RefSeq | GRCh38/hg38 |
NM_001126112 | chr17:g.7673745T>A | c.875A>T | p.K292I | RefSeq | GRCh38/hg38 |
NM_001126114.3 | chr17:g.7673745T>A | c.875A>T | p.K292I | RefSeq | GRCh38/hg38 |
NM_001407262.1 | chr17:g.7673745T>A | c.875A>T | p.K292I | RefSeq | GRCh38/hg38 |
NM_001407270.1 | chr17:g.7673745T>A | c.875A>T | p.K292I | RefSeq | GRCh38/hg38 |
NM_001126114 | chr17:g.7673745T>A | c.875A>T | p.K292I | RefSeq | GRCh38/hg38 |
NM_001126112.2 | chr17:g.7673745T>A | c.875A>T | p.K292I | RefSeq | GRCh38/hg38 |
NM_001126113.3 | chr17:g.7673745T>A | c.875A>T | p.K292I | RefSeq | GRCh38/hg38 |
NM_001126113 | chr17:g.7673745T>A | c.875A>T | p.K292I | RefSeq | GRCh38/hg38 |
NM_001126112.3 | chr17:g.7673745T>A | c.875A>T | p.K292I | RefSeq | GRCh38/hg38 |
NM_001126113.2 | chr17:g.7673745T>A | c.875A>T | p.K292I | RefSeq | GRCh38/hg38 |
NM_001407266.1 | chr17:g.7673745T>A | c.875A>T | p.K292I | RefSeq | GRCh38/hg38 |
NM_001407268.1 | chr17:g.7673745T>A | c.875A>T | p.K292I | RefSeq | GRCh38/hg38 |
NM_000546 | chr17:g.7673745T>A | c.875A>T | p.K292I | RefSeq | GRCh38/hg38 |
NM_000546.6 | chr17:g.7673745T>A | c.875A>T | p.K292I | RefSeq | GRCh38/hg38 |
NM_000546.5 | chr17:g.7673745T>A | c.875A>T | p.K292I | RefSeq | GRCh38/hg38 |
NM_001407264.1 | chr17:g.7673745T>A | c.875A>T | p.K292I | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|