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Gene | TP53 |
Variant | F212Y |
Impact List | missense |
Protein Effect | gain of function - predicted |
Gene Variant Descriptions | TP53 F212Y lies within the DNA-binding domain of the Tp53 protein (PMID: 20978130). F212Y is predicted to confer a gain of function to the Tp53 protein as demonstrated by increased ability to induce apoptosis in cultured cells (PMID: 15781620). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 act mut TP53 F212Y TP53 mutant TP53 exon6 TP53 F212Y |
Transcript | NM_000546.6 |
gDNA | chr17:g.7674896A>T |
cDNA | c.635T>A |
Protein | p.F212Y |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |