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Gene APC
Variant A1296fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC A1296fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1296 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1296fs has not been characterized, however, due to the effects of other truncation mutations downstream of A1296 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC A1296fs

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Transcript NM_000038.6
gDNA chr5:g.(112839479_112839480)
cDNA c.(3886_3885)
Protein p.A1296fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127510 chr5:g.(112839479_112839480) c.(3886_3885) p.A1296fs RefSeq GRCh38/hg38
NM_000038 chr5:g.(112839479_112839480) c.(3886_3885) p.A1296fs RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.(112839479_112839480) c.(3886_3885) p.A1296fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112839479_112839480) c.(3886_3885) p.A1296fs RefSeq GRCh38/hg38
NM_000038.5 chr5:g.(112839479_112839480) c.(3886_3885) p.A1296fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112839479_112839480) c.(3886_3885) p.A1296fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112839479_112839480) c.(3886_3885) p.A1296fs RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.(112839479_112839480) c.(3886_3885) p.A1296fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112839479_112839480) c.(3886_3885) p.A1296fs RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries