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Gene APC
Variant A1305fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC A1305fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1305 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1305fs has not been characterized, however, due to the effects of other truncation mutations downstream of A1305 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC A1305fs

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Transcript NM_000038.6
gDNA chr5:g.(112839506_112839507)
cDNA c.(3913_3912)
Protein p.A1305fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354895.2 chr5:g.(112839506_112839507) c.(3913_3912) p.A1305fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112839506_112839507) c.(3913_3912) p.A1305fs RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.(112839506_112839507) c.(3913_3912) p.A1305fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112839506_112839507) c.(3913_3912) p.A1305fs RefSeq GRCh38/hg38
NM_000038.5 chr5:g.(112839506_112839507) c.(3913_3912) p.A1305fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112839506_112839507) c.(3913_3912) p.A1305fs RefSeq GRCh38/hg38
NM_001127510 chr5:g.(112839506_112839507) c.(3913_3912) p.A1305fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112839506_112839507) c.(3913_3912) p.A1305fs RefSeq GRCh38/hg38
NM_000038 chr5:g.(112839506_112839507) c.(3913_3912) p.A1305fs RefSeq GRCh38/hg38

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Molecular Profile Protein Effect Treatment Approaches
APC A1305fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor