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Gene APC
Variant A1402fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC A1402fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1402 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1402fs has not been characterized, however, due to the effects of other truncation mutations downstream of A1402 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC A1402fs

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Transcript NM_000038.6
gDNA chr5:g.(112839797_112839798)
cDNA c.(4204_4203)
Protein p.A1402fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127510.3 chr5:g.(112839797_112839798) c.(4204_4203) p.A1402fs RefSeq GRCh38/hg38
NM_001127510 chr5:g.(112839797_112839798) c.(4204_4203) p.A1402fs RefSeq GRCh38/hg38
NM_001407457.1 chr5:g.(112840046_112840047) c.(4204_4203) p.A1402fs RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.(112839797_112839798) c.(4204_4203) p.A1402fs RefSeq GRCh38/hg38
NM_001407454.1 chr5:g.(112840046_112840047) c.(4204_4203) p.A1402fs RefSeq GRCh38/hg38
NM_000038 chr5:g.(112839797_112839798) c.(4204_4203) p.A1402fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112839797_112839798) c.(4204_4203) p.A1402fs RefSeq GRCh38/hg38
NM_000038.5 chr5:g.(112839797_112839798) c.(4204_4203) p.A1402fs RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.(112839797_112839798) c.(4204_4203) p.A1402fs RefSeq GRCh38/hg38
NM_001407455.1 chr5:g.(112840046_112840047) c.(4204_4203) p.A1402fs RefSeq GRCh38/hg38
NM_001407456.1 chr5:g.(112840046_112840047) c.(4204_4203) p.A1402fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112839797_112839798) c.(4204_4203) p.A1402fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112839797_112839798) c.(4204_4203) p.A1402fs RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries