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Gene APC
Variant A1446fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC A1446fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1446 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1446fs has not been characterized, however, due to the effects of other truncation mutations downstream of A1446 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC A1446fs

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Transcript NM_000038.6
gDNA chr5:g.(112839929_112839930)
cDNA c.(4336_4335)
Protein p.A1446fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000038 chr5:g.(112839929_112839930) c.(4336_4335) p.A1446fs RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.(112839929_112839930) c.(4336_4335) p.A1446fs RefSeq GRCh38/hg38
NM_001354905.2 chr5:g.(112840409_112840410) c.(4336_4335) p.A1446fs RefSeq GRCh38/hg38
NM_001354899.1 chr5:g.(112840013_112840014) c.(4336_4335) p.A1446fs RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.(112839929_112839930) c.(4336_4335) p.A1446fs RefSeq GRCh38/hg38
NM_001127510 chr5:g.(112839929_112839930) c.(4336_4335) p.A1446fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112839929_112839930) c.(4336_4335) p.A1446fs RefSeq GRCh38/hg38
NM_001354898.2 chr5:g.(112840004_112840005) c.(4336_4335) p.A1446fs RefSeq GRCh38/hg38
NM_001354898.1 chr5:g.(112840004_112840005) c.(4336_4335) p.A1446fs RefSeq GRCh38/hg38
NM_001354905.1 chr5:g.(112840409_112840410) c.(4336_4335) p.A1446fs RefSeq GRCh38/hg38
NM_000038.5 chr5:g.(112839929_112839930) c.(4336_4335) p.A1446fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112839929_112839930) c.(4336_4335) p.A1446fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112839929_112839930) c.(4336_4335) p.A1446fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112839929_112839930) c.(4336_4335) p.A1446fs RefSeq GRCh38/hg38
NM_001354899.2 chr5:g.(112840013_112840014) c.(4336_4335) p.A1446fs RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries