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Gene APC
Variant A1470fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC A1470fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1470 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). A1470fs has not been characterized, however, due to the effects of other truncation mutations downstream of A1470 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC A1470fs

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Transcript NM_000038.6
gDNA chr5:g.(112840001_112840002)
cDNA c.(4408_4407)
Protein p.A1470fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354895.2 chr5:g.(112840001_112840002) c.(4408_4407) p.A1470fs RefSeq GRCh38/hg38
NM_000038 chr5:g.(112840001_112840002) c.(4408_4407) p.A1470fs RefSeq GRCh38/hg38
NM_001407470.1 chr5:g.(112840850_112840851) c.(4408_4407) p.A1470fs RefSeq GRCh38/hg38
NM_001354906.2 chr5:g.(112840850_112840851) c.(4408_4407) p.A1470fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112840001_112840002) c.(4408_4407) p.A1470fs RefSeq GRCh38/hg38
NM_001407457.1 chr5:g.(112840250_112840251) c.(4408_4407) p.A1470fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112840001_112840002) c.(4408_4407) p.A1470fs RefSeq GRCh38/hg38
NM_000038.5 chr5:g.(112840001_112840002) c.(4408_4407) p.A1470fs RefSeq GRCh38/hg38
NM_001354897.2 chr5:g.(112839971_112839972) c.(4408_4407) p.A1470fs RefSeq GRCh38/hg38
NM_001407455.1 chr5:g.(112840250_112840251) c.(4408_4407) p.A1470fs RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.(112840001_112840002) c.(4408_4407) p.A1470fs RefSeq GRCh38/hg38
NM_001407454.1 chr5:g.(112840250_112840251) c.(4408_4407) p.A1470fs RefSeq GRCh38/hg38
NM_001407456.1 chr5:g.(112840250_112840251) c.(4408_4407) p.A1470fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112840001_112840002) c.(4408_4407) p.A1470fs RefSeq GRCh38/hg38
NM_001354906.1 chr5:g.(112840850_112840851) c.(4408_4407) p.A1470fs RefSeq GRCh38/hg38
NM_001127510 chr5:g.(112840001_112840002) c.(4408_4407) p.A1470fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112840001_112840002) c.(4408_4407) p.A1470fs RefSeq GRCh38/hg38
NM_001354897.1 chr5:g.(112839971_112839972) c.(4408_4407) p.A1470fs RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
APC A1470fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor