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Gene APC
Variant D1422N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions APC D1422N lies within the beta-catenin binding and downregulation region of the Apc protein (PMID: 14672538). D1422N has been identified in sequencing studies (PMID: 18632876), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

APC mutant APC D1422N

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Transcript NM_000038.6
gDNA chr5:g.112839858G>A
cDNA c.4264G>A
Protein p.D1422N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127510.3 chr5:g.112839858G>A c.4264G>A p.D1422N RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112839858G>A c.4264G>A p.D1422N RefSeq GRCh38/hg38
NM_000038 chr5:g.112839858G>A c.4264G>A p.D1422N RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112839858G>A c.4264G>A p.D1422N RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112839858G>A c.4264G>A p.D1422N RefSeq GRCh38/hg38
NM_001407446.1 chr5:g.112839774G>A c.4264G>A p.D1422N RefSeq GRCh38/hg38
NM_001127510 chr5:g.112839858G>A c.4264G>A p.D1422N RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112839858G>A c.4264G>A p.D1422N RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112839858G>A c.4264G>A p.D1422N RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112839858G>A c.4264G>A p.D1422N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
APC D1422N unknown