Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene APC
Variant E1577*
Impact List nonsense
Protein Effect unknown
Gene Variant Descriptions APC E1577* results in a premature truncation of the Apc protein at amino acid 1577 of 2843 (UniProt.org). E1577* is associated with elevated beta-catenin in a cell line (PMID: 10874025), but has not been fully biochemically characterized and therefore, its effect on Apc protein function is unknown.
Associated Drug Resistance
Category Variants Paths

APC mutant APC E1577*

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_000038.6
gDNA chr5:g.112840323G>T
cDNA c.4729G>T
Protein p.E1577*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354895.1 chr5:g.112840323G>T c.4729G>T p.E1577* RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112840323G>T c.4729G>T p.E1577* RefSeq GRCh38/hg38
NM_001127510 chr5:g.112840323G>T c.4729G>T p.E1577* RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112840323G>T c.4729G>T p.E1577* RefSeq GRCh38/hg38
NM_001354902.1 chr5:g.112840596G>T c.4729G>T p.E1577* RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112840323G>T c.4729G>T p.E1577* RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112840323G>T c.4729G>T p.E1577* RefSeq GRCh38/hg38
NM_000038 chr5:g.112840323G>T c.4729G>T p.E1577* RefSeq GRCh38/hg38
NM_001354902.2 chr5:g.112840596G>T c.4729G>T p.E1577* RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112840323G>T c.4729G>T p.E1577* RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112840323G>T c.4729G>T p.E1577* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References