Gene Variant Detail

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Gene ATR
Variant H90Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ATR H90Y does not lie within any known functional domains of the Atr protein (UniProt.org). H90Y has been identified in sequencing studies (PMID: 29793804, PMID: 25528188), but has not been biochemically characterized and therefore, its effect on Atr protein function is unknown (PubMed, Sep 2024).
Associated Drug Resistance
Category Variants Paths

ATR mutant ATR H90Y

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Transcript NM_001184.4
gDNA chr3:g.142566145G>A
cDNA c.268C>T
Protein p.H90Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047448364.1 chr3:g.142566145G>A c.268C>T p.H90Y RefSeq GRCh38/hg38
XM_047448362.1 chr3:g.142566145G>A c.268C>T p.H90Y RefSeq GRCh38/hg38
XM_047448363.1 chr3:g.142566145G>A c.268C>T p.H90Y RefSeq GRCh38/hg38
NM_001354579.1 chr3:g.142566145G>A c.268C>T p.H90Y RefSeq GRCh38/hg38
NM_001184.4 chr3:g.142566145G>A c.268C>T p.H90Y RefSeq GRCh38/hg38
XM_011512925 chr3:g.142566145G>A c.268C>T p.H90Y RefSeq GRCh38/hg38
XM_011512924.1 chr3:g.142566145G>A c.268C>T p.H90Y RefSeq GRCh38/hg38
NM_001354579.2 chr3:g.142566145G>A c.268C>T p.H90Y RefSeq GRCh38/hg38
XM_047448361.1 chr3:g.142566145G>A c.268C>T p.H90Y RefSeq GRCh38/hg38
XM_011512925.2 chr3:g.142566145G>A c.268C>T p.H90Y RefSeq GRCh38/hg38
NM_001184 chr3:g.142566145G>A c.268C>T p.H90Y RefSeq GRCh38/hg38
XM_011512926 chr3:g.142566145G>A c.268C>T p.H90Y RefSeq GRCh38/hg38
XM_011512924 chr3:g.142566145G>A c.268C>T p.H90Y RefSeq GRCh38/hg38
NM_001184.3 chr3:g.142566145G>A c.268C>T p.H90Y RefSeq GRCh38/hg38
XM_017006643 chr3:g.142566145G>A c.268C>T p.H90Y RefSeq GRCh38/hg38
XM_011512925.1 chr3:g.142566145G>A c.268C>T p.H90Y RefSeq GRCh38/hg38
XM_047448360.1 chr3:g.142566145G>A c.268C>T p.H90Y RefSeq GRCh38/hg38
XM_011512924.2 chr3:g.142566145G>A c.268C>T p.H90Y RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References