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Gene | ATR |
Variant | R2425Q |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | ATR R2425Q lies within the PI3K/PI4K domain of the Atr protein (UniProt.org). R2425Q has been identified in the scientific literature (PMID: 31748433, PMID: 27693639, PMID: 33685866), but has not been biochemically characterized and therefore, its effect on Atr protein function is unknown (PubMed, Aug 2024). |
Associated Drug Resistance | |
Category Variants Paths |
ATR mutant ATR R2425Q |
Transcript | NM_001184.4 |
gDNA | chr3:g.142459302C>T |
cDNA | c.7274G>A |
Protein | p.R2425Q |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001184 | chr3:g.142459302C>T | c.7274G>A | p.R2425Q | RefSeq | GRCh38/hg38 |
NM_001184.3 | chr3:g.142459302C>T | c.7274G>A | p.R2425Q | RefSeq | GRCh38/hg38 |
NM_001184.4 | chr3:g.142459302C>T | c.7274G>A | p.R2425Q | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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