Gene Variant Detail

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Gene FBXW7
Variant V154I
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FBXW7 V154I does not lie within any known functional domains of the Fbxw7 protein (UniProt.org). V154I results in nuclear and subnuclear localization and Notch1 intracellular domain binding similar to wild-type Fbxw7 in culture (PMID: 30510140), and therefore, is predicted to have no effect on Fbxw7 protein function.
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 V154I

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Transcript NM_033632.3
gDNA chr4:g.152411344C>T
cDNA c.460G>A
Protein p.V154I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001349798.1 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
NM_001257069 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
XM_011532085.3 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
XM_047415898.1 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
XM_011532083 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
XM_024454121.1 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
NM_001349798.2 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
XM_011532084 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
NM_001257069.1 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
XM_011532085 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
NM_001257069.1 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
XM_047415901.1 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
XM_017008362 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
NM_033632 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38
XM_024454123.2 chr4:g.152411344C>T c.460G>A p.V154I RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References