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Gene JAK3
Variant R943C
Impact List missense
Protein Effect unknown
Gene Variant Descriptions JAK3 R943C lies within protein kinase domain 2 of the Jak3 protein (UniProt.org). R943C has not been characterized in the scientific literature and therefore, its effect on Jak3 protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

JAK3 mutant JAK3 R943C

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Transcript NM_000215.4
gDNA chr19:g.17831379G>A
cDNA c.2827C>T
Protein p.R943C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000215 chr19:g.17831379G>A c.2827C>T p.R943C RefSeq GRCh38/hg38
NM_000215.4 chr19:g.17831379G>A c.2827C>T p.R943C RefSeq GRCh38/hg38
XM_047438786.1 chr19:g.17831379G>A c.2827C>T p.R943C RefSeq GRCh38/hg38
NM_000215.3 chr19:g.17831379G>A c.2827C>T p.R943C RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References