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Gene RAD51C
Variant T287A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51C T287A does not lie within any known functional domains of the Rad51c protein (UniProt.org). T287A is conflicting as it demonstrates homologous recombination activity similar to wild-type Rad51c in cultured cells, rescues survival in Rad51c-null cells in culture, and results in variable interaction with Rad51b, Rad51d, and Xrcc3 in one study (PMID: 36099300), but demonstrates a partial defect in homologous recombination (PMID: 22167183, PMID: 21980511, PMID: 25292178) and decreased association with Xrcc3 in other studies (PMID: 22167183, PMID: 21980511), and therefore, its effect on Rad51c protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C T287A

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Transcript NM_058216.3
gDNA chr17:g.58720767A>G
cDNA c.859A>G
Protein p.T287A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_058216 chr17:g.58720767A>G c.859A>G p.T287A RefSeq GRCh38/hg38
XM_006722001 chr17:g.58720767A>G c.859A>G p.T287A RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58720767A>G c.859A>G p.T287A RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58720767A>G c.859A>G p.T287A RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58720767A>G c.859A>G p.T287A RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58720767A>G c.859A>G p.T287A RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58720767A>G c.859A>G p.T287A RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58720767A>G c.859A>G p.T287A RefSeq GRCh38/hg38
XM_006722002 chr17:g.58720767A>G c.859A>G p.T287A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries