MSH6 T1085fs
Gene Variant Detail

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Gene MSH6
Variant T1085fs
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions MSH6 T1085fs results in a change in the amino acid sequence of the Msh6 protein beginning at aa 1085 of 1360, likely resulting in premature truncation of the functional protein (UniProt.org). T1085fs is associated with loss of Msh6 expression in a patient sample (PMID: 40625767), but has not been fully biochemically characterized and therefore, its effect on Msh6 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

MSH6 mutant MSH6 T1085fs

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Transcript NM_000179.3
gDNA chr2:g.(47803499_47803500)
cDNA c.(3253_3252)
Protein p.T1085fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406800.1 chr2:g.(47803499_47803500) c.(3253_3252) p.T1085fs RefSeq GRCh38/hg38
NM_001406796.1 chr2:g.(47803499_47803500) c.(3253_3252) p.T1085fs RefSeq GRCh38/hg38
NM_001406808.1 chr2:g.(47803499_47803500) c.(3253_3252) p.T1085fs RefSeq GRCh38/hg38
NM_000179.2 chr2:g.(47803499_47803500) c.(3253_3252) p.T1085fs RefSeq GRCh38/hg38
XM_024452819.1 chr2:g.(47803499_47803500) c.(3253_3252) p.T1085fs RefSeq GRCh38/hg38
NM_001406809.1 chr2:g.(47803499_47803500) c.(3253_3252) p.T1085fs RefSeq GRCh38/hg38
NM_000179.3 chr2:g.(47803499_47803500) c.(3253_3252) p.T1085fs RefSeq GRCh38/hg38
NM_000179 chr2:g.(47803499_47803500) c.(3253_3252) p.T1085fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries