Gene Variant Detail

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Gene ATR
Variant K764E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ATR K764E does not lie within any known functional domains of the Atr protein (UniProt.org). K764E has been identified in sequencing studies (PMID: 28522871, PMID: 31591497, PMID: 31874108), but has not been biochemically characterized and therefore, its effect on Atr protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

ATR mutant ATR K764E

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Transcript NM_001184.4
gDNA chr3:g.142555928T>C
cDNA c.2290A>G
Protein p.K764E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001184.3 chr3:g.142555928T>C c.2290A>G p.K764E RefSeq GRCh38/hg38
XM_047448360.1 chr3:g.142555928T>C c.2290A>G p.K764E RefSeq GRCh38/hg38
XM_047448362.1 chr3:g.142555928T>C c.2290A>G p.K764E RefSeq GRCh38/hg38
XM_047448363.1 chr3:g.142555928T>C c.2290A>G p.K764E RefSeq GRCh38/hg38
XM_047448361.1 chr3:g.142555928T>C c.2290A>G p.K764E RefSeq GRCh38/hg38
XM_011512924 chr3:g.142555928T>C c.2290A>G p.K764E RefSeq GRCh38/hg38
XM_011512926 chr3:g.142555928T>C c.2290A>G p.K764E RefSeq GRCh38/hg38
XM_011512924.1 chr3:g.142555928T>C c.2290A>G p.K764E RefSeq GRCh38/hg38
XM_011512924.2 chr3:g.142555928T>C c.2290A>G p.K764E RefSeq GRCh38/hg38
XM_047448364.1 chr3:g.142555928T>C c.2290A>G p.K764E RefSeq GRCh38/hg38
NM_001184 chr3:g.142555928T>C c.2290A>G p.K764E RefSeq GRCh38/hg38
NM_001184.4 chr3:g.142555928T>C c.2290A>G p.K764E RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References