TP53 dec exp
Gene Variant Detail

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Gene TP53
Variant dec exp
Impact List none
Protein Effect no effect
Gene Variant Descriptions TP53 dec exp indicates decreased expression of the Tp53 protein. However, the mechanism causing the decreased expression is unspecified.
Associated Drug Resistance
Category Variants Paths

TP53 dec exp

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 dec exp high grade glioma sensitive AZ32 + Radiotherapy Preclinical - Cell culture Actionable In a preclinical study, shRNA knock-down of TP53 in malignant glioma cells enhanced sensitivity to the combination of AZ32 and radiation compared to TP53 wild-type cells in culture, and resulted in a greater decrease in cell survival and increased mitotic failure compared to either treatment treatment alone (PMID: 29769307). 29769307