MSH6 E544D
Gene Variant Detail

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Gene MSH6
Variant E544D
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MSH6 E544D lies within an MSH2-binding region of the Msh6 protein (PMID: 12019211). E544D has not been characterized in the scientific literature and therefore, its effect on Msh6 protein function is unknown (PubMed, Oct 2025).
Associated Drug Resistance
Category Variants Paths

MSH6 mutant MSH6 E544D

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Transcript NM_000179.3
gDNA chr2:g.47799615A>C
cDNA c.1632A>C
Protein p.E544D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406802.1 chr2:g.47799519G>C c.1632G>C p.E544D RefSeq GRCh38/hg38
NM_001281494.1 chr2:g.47800521A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_001406812.1 chr2:g.47800521A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_001406795.1 chr2:g.47799519G>C c.1632G>C p.E544D RefSeq GRCh38/hg38
NM_001406803.1 chr2:g.47799615A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
XM_024452819.1 chr2:g.47799615A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_001406796.1 chr2:g.47799615A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_001281494 chr2:g.47800521A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_001406808.1 chr2:g.47799615A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_001281493.2 chr2:g.47800521A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_001406816.1 chr2:g.47800521A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_001406814.1 chr2:g.47800521A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_001406809.1 chr2:g.47799615A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_000179.2 chr2:g.47799615A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_001406798.1 chr2:g.47799615A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
XM_024452822.1 chr2:g.47800521A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_001406800.1 chr2:g.47799615A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_001281493 chr2:g.47800521A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_001406829.1 chr2:g.47800521A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_000179.3 chr2:g.47799615A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_000179 chr2:g.47799615A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_001406823.1 chr2:g.47800521A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_001406815.1 chr2:g.47800521A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_001281493.1 chr2:g.47800521A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_001406811.1 chr2:g.47800521A>C c.1632A>C p.E544D RefSeq GRCh38/hg38
NM_001281494.2 chr2:g.47800521A>C c.1632A>C p.E544D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
MSH6 E544D unknown