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Gene NRAS
Variant G60E
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions NRAS G60E lies within the nucleotide binding domain of the Nras protein (UniProt.org). G60E confers a loss of function on Nras as indicated by accumulation of GTP-bound Nras, loss of response to GTPase-activating proteins, leading to activation of downstream signaling and cell proliferation in culture (PMID: 19966803, PMID: 19075190).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G60E

NRAS mutant NRAS exon3 NRAS G60E

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Transcript NM_002524.5
gDNA chr1:g.114713911C>T
cDNA c.179G>A
Protein p.G60E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524 chr1:g.114713911C>T c.179G>A p.G60E RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114713911C>T c.179G>A p.G60E RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114713911C>T c.179G>A p.G60E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References