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NRAS G60E - Gene Variant Detail

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Gene NRAS
Variant G60E
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions NRAS G60E lies within the nucleotide binding domain of the Nras protein (UniProt.org). G60E confers a loss of function on Nras as indicated by accumulation of GTP-bound Nras, loss of response to GTPase-activating proteins, leading to activation of downstream signaling and cell proliferation in culture (PMID: 19966803, PMID: 19075190).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS G60E

NRAS mutant NRAS exon3 NRAS G60E

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Transcript NM_002524.5
gDNA chr1:g.114713911C>T
cDNA c.179G>A
Protein p.G60E
Source Database RefSeq
Genome Build GRCh38/hg38

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