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Gene TP53
Variant G105D
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 G105D lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). G105D has been identified in the scientific literature (PMID: 16000567, PMID: 27273737), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon4 TP53 G105D

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Transcript NM_000546.6
gDNA chr17:g.7676055C>T
cDNA c.314G>A
Protein p.G105D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407266.1 chr17:g.7676055C>T c.314G>A p.G105D RefSeq GRCh38/hg38
NM_001126112 chr17:g.7676055C>T c.314G>A p.G105D RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7676055C>T c.314G>A p.G105D RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7676055C>T c.314G>A p.G105D RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7676055C>T c.314G>A p.G105D RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7676055C>T c.314G>A p.G105D RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7676055C>T c.314G>A p.G105D RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7676055C>T c.314G>A p.G105D RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7676055C>T c.314G>A p.G105D RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7676055C>T c.314G>A p.G105D RefSeq GRCh38/hg38
NM_001126113 chr17:g.7676055C>T c.314G>A p.G105D RefSeq GRCh38/hg38
NM_001126114 chr17:g.7676055C>T c.314G>A p.G105D RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7676055C>T c.314G>A p.G105D RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7676055C>T c.314G>A p.G105D RefSeq GRCh38/hg38
NM_000546 chr17:g.7676055C>T c.314G>A p.G105D RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7676055C>T c.314G>A p.G105D RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7676055C>T c.314G>A p.G105D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References