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Gene TP53
Variant D7A
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 D7A lies within the CCAR2 and HRMT1L2-interacting regions and the transcription activation region of the Tp53 protein (UniProt.org). D7A is predicted to confer a loss of function to the Tp53 protein, as demonstrated by reduced Pimpt-mediated Tp53 methylation (PMID: 22735455).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon2 TP53 D7A

TP53 mutant TP53 inact mut TP53 D7A

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Transcript NM_000546.6
gDNA chr17:g.7676575T>G
cDNA c.20A>C
Protein p.D7A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407266.1 chr17:g.7676575T>G c.20A>C p.D7A RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7676575T>G c.20A>C p.D7A RefSeq GRCh38/hg38
NM_001126112 chr17:g.7676575T>G c.20A>C p.D7A RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7676575T>G c.20A>C p.D7A RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7676575T>G c.20A>C p.D7A RefSeq GRCh38/hg38
NM_001126114 chr17:g.7676575T>G c.20A>C p.D7A RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7676575T>G c.20A>C p.D7A RefSeq GRCh38/hg38
NM_000546 chr17:g.7676575T>G c.20A>C p.D7A RefSeq GRCh38/hg38
NM_001126113 chr17:g.7676575T>G c.20A>C p.D7A RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7676575T>G c.20A>C p.D7A RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7676575T>G c.20A>C p.D7A RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7676575T>G c.20A>C p.D7A RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7676575T>G c.20A>C p.D7A RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7676575T>G c.20A>C p.D7A RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7676575T>G c.20A>C p.D7A RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7676575T>G c.20A>C p.D7A RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7676575T>G c.20A>C p.D7A RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References