TP53 V147L
Gene Variant Detail

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Gene TP53
Variant V147L
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions TP53 V147L lies within the DNA-binding domain of the Tp53 protein (PMID: 21760703). V147L retains the ability to bind chromatin and the promoter regions of MDM2 and CDKN1A, and to upregulate the expression of PUMA, CDKN1A, and MDM2 genes to similar levels of wild-type protein in culture (PMID: 41504628), and therefore, is predicted to have no effect on Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 V147L

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Transcript NM_000546.6
gDNA chr17:g.7675173C>G
cDNA c.439G>C
Protein p.V147L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126114 chr17:g.7675173C>G c.439G>C p.V147L RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675173C>G c.439G>C p.V147L RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675173C>G c.439G>C p.V147L RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675173C>G c.439G>C p.V147L RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675173C>G c.439G>C p.V147L RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675173C>G c.439G>C p.V147L RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675173C>G c.439G>C p.V147L RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675173C>G c.439G>C p.V147L RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675173C>G c.439G>C p.V147L RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675173C>G c.439G>C p.V147L RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675173C>G c.439G>C p.V147L RefSeq GRCh38/hg38
NM_001126112 chr17:g.7675173C>G c.439G>C p.V147L RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675173C>G c.439G>C p.V147L RefSeq GRCh38/hg38
NM_001126113 chr17:g.7675173C>G c.439G>C p.V147L RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675173C>G c.439G>C p.V147L RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675173C>G c.439G>C p.V147L RefSeq GRCh38/hg38
NM_000546 chr17:g.7675173C>G c.439G>C p.V147L RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References