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Gene CSF3R
Variant A470T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions CSF3R A470T lies within fibronectin type-III domain 4 of the Csf3r protein (UniProt.org). A470T has been identified in sequencing studies (PMID: 28825054), but has not been biochemically characterized and therefore, its effect on Csf3r protein function is unknown (PubMed, Oct 2024).
Associated Drug Resistance
Category Variants Paths

CSF3R mutant CSF3R A470T

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Transcript NM_000760.4
gDNA chr1:g.36469718C>T
cDNA c.1408G>A
Protein p.A470T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_156039.3 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38
NM_172313.3 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38
NM_172313.2 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38
XM_011540749 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38
NM_000760.4 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38
XM_017000370.1 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38
XM_005270493 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38
XM_017000370 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38
NM_156039 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38
NM_156039.3 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38
XM_005270493.1 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38
NM_000760 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38
XM_005270493.1 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38
XM_047446753.1 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38
XM_011540749.1 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38
XM_011540748 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38
XM_011540749.1 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38
XM_011540748.3 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38
NM_000760.3 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38
NM_172313 chr1:g.36469718C>T c.1408G>A p.A470T RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CSF3R mutant bone marrow cancer not applicable N/A Clinical Study Emerging In clinical studies, high frequency of CSF3R mutations was identified in patients with chronic neutrophilic leukemia (PMID: 23656643, PMID: 24081659), suggesting that this may serve as a future diagnostic biomarker (PMID: 24441292). 24081659 23656643 24441292