We’re improving your experience!

Starting April 21, you’ll be asked to log in or sign up for a free account after viewing 10 content pages each month.

Don’t worry—creating an account is quick and easy, and it comes with added benefits! Once logged in, you’ll not only continue accessing the content you already enjoy, but you’ll also unlock exclusive features like interactive donut plots for variant protein effects and variant impacts across the gene.

Stay tuned for these updates, and thank you for being part of our community!

TP53 K305N - Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene TP53
Variant K305N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 K305N lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). K305N results in a loss of nuclear localization of Tp53, but retains the ability to interact with wild-type Tp53 and Mdm2 (PMID: 11127820), demonstrates variable cellular localization under stress conditions in culture (PMID: 16115632), and cellular invasion and radiation-induced cell death similar to wild-type in culture (PMID: 28377455), and therefore, its effect on Tp53 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon8 TP53 K305N

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_000546.6
gDNA chr17:g.7673705C>G
cDNA c.915G>C
Protein p.K305N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546.5 chr17:g.7673705C>G c.915G>C p.K305N RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7673705C>G c.915G>C p.K305N RefSeq GRCh38/hg38
NM_001126114 chr17:g.7673705C>G c.915G>C p.K305N RefSeq GRCh38/hg38
NM_001126112 chr17:g.7673705C>G c.915G>C p.K305N RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7673705C>G c.915G>C p.K305N RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7673705C>G c.915G>C p.K305N RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7673705C>G c.915G>C p.K305N RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7673705C>G c.915G>C p.K305N RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7673705C>G c.915G>C p.K305N RefSeq GRCh38/hg38
NM_001126113 chr17:g.7673705C>G c.915G>C p.K305N RefSeq GRCh38/hg38
NM_000546 chr17:g.7673705C>G c.915G>C p.K305N RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7673705C>G c.915G>C p.K305N RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7673705C>G c.915G>C p.K305N RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7673705C>G c.915G>C p.K305N RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7673705C>G c.915G>C p.K305N RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7673705C>G c.915G>C p.K305N RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7673705C>G c.915G>C p.K305N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References