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Gene TP53
Variant G154C
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 G154C lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). G154C has been identified in sequencing studies (PMID: 26718964), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Jan 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 G154C

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Transcript NM_000546.6
gDNA chr17:g.7675152C>A
cDNA c.460G>T
Protein p.G154C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.3 chr17:g.7675152C>A c.460G>T p.G154C RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675152C>A c.460G>T p.G154C RefSeq GRCh38/hg38
NM_000546 chr17:g.7675152C>A c.460G>T p.G154C RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675152C>A c.460G>T p.G154C RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675152C>A c.460G>T p.G154C RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675152C>A c.460G>T p.G154C RefSeq GRCh38/hg38
NM_001126114 chr17:g.7675152C>A c.460G>T p.G154C RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675152C>A c.460G>T p.G154C RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675152C>A c.460G>T p.G154C RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675152C>A c.460G>T p.G154C RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675152C>A c.460G>T p.G154C RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675152C>A c.460G>T p.G154C RefSeq GRCh38/hg38
NM_001126113 chr17:g.7675152C>A c.460G>T p.G154C RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675152C>A c.460G>T p.G154C RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675152C>A c.460G>T p.G154C RefSeq GRCh38/hg38
NM_001126112 chr17:g.7675152C>A c.460G>T p.G154C RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675152C>A c.460G>T p.G154C RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References