TP53 L344Q
Gene Variant Detail

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Gene TP53
Variant L344Q
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 L344Q lies within the tetramerization domain of the Tp53 protein (PMID: 20978130). L344Q results in decreased Tp53 oligomer formation and transcriptional activity in yeast (PMID: 16007150), and the corresponding canine variant (L332Q) demonstrates impaired tetramerization, but not dimerization (PMID: 29750295), and therefore, is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon10 TP53 L344Q

TP53 mutant TP53 inact mut TP53 L344Q

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Transcript NM_000546.6
gDNA chr17:g.7670678A>T
cDNA c.1031T>A
Protein p.L344Q
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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