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Gene TP53
Variant S96A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 S96A lies within the CCAR2 and WWOX-interacting regions of the Tp53 protein (UniProt.org). S96A is phosphorylated to similar levels as wild-type Tp53 by Nek2 in culture (PMID: 30266789), but has not been fully biochemically characterized and therefore, its effect on Tp53 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon4 TP53 S96A

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Transcript NM_000546.6
gDNA chr17:g.7676083A>C
cDNA c.286T>G
Protein p.S96A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546.6 chr17:g.7676083A>C c.286T>G p.S96A RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7676083A>C c.286T>G p.S96A RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7676083A>C c.286T>G p.S96A RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7676083A>C c.286T>G p.S96A RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7676083A>C c.286T>G p.S96A RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7676083A>C c.286T>G p.S96A RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7676083A>C c.286T>G p.S96A RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7676083A>C c.286T>G p.S96A RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7676083A>C c.286T>G p.S96A RefSeq GRCh38/hg38
NM_000546 chr17:g.7676083A>C c.286T>G p.S96A RefSeq GRCh38/hg38
NM_001126113 chr17:g.7676083A>C c.286T>G p.S96A RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7676083A>C c.286T>G p.S96A RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7676083A>C c.286T>G p.S96A RefSeq GRCh38/hg38
NM_001126114 chr17:g.7676083A>C c.286T>G p.S96A RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7676083A>C c.286T>G p.S96A RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7676083A>C c.286T>G p.S96A RefSeq GRCh38/hg38
NM_001126112 chr17:g.7676083A>C c.286T>G p.S96A RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References