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TP53 S227P - Gene Variant Detail

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Gene TP53
Variant S227P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 S227P lies within the DNA-binding domain of the Tp53 protein (PMID: 21760703). S227P has been identified in the scientific literature (PMID: 26687995, PMID: 29979965), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2025).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 S227P

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Transcript NM_000546.6
gDNA chr17:g.7674284A>G
cDNA c.679T>C
Protein p.S227P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126112.3 chr17:g.7674284A>G c.679T>C p.S227P RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674284A>G c.679T>C p.S227P RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674284A>G c.679T>C p.S227P RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674284A>G c.679T>C p.S227P RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674284A>G c.679T>C p.S227P RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674284A>G c.679T>C p.S227P RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674284A>G c.679T>C p.S227P RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674284A>G c.679T>C p.S227P RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674284A>G c.679T>C p.S227P RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674284A>G c.679T>C p.S227P RefSeq GRCh38/hg38
NM_000546 chr17:g.7674284A>G c.679T>C p.S227P RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674284A>G c.679T>C p.S227P RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674284A>G c.679T>C p.S227P RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674284A>G c.679T>C p.S227P RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674284A>G c.679T>C p.S227P RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674284A>G c.679T>C p.S227P RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674284A>G c.679T>C p.S227P RefSeq GRCh38/hg38

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Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries