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Gene | TP53 |
Variant | D259N |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | TP53 D259N lies within the DNA-binding domain of the Tp53 protein (PMID: 15510160). D259N results in altered Tp53 transactivation activity in yeast assays (PMID: 11896595), but has not been characterized in human cells and therefore, its effect on Tp53 protein function is unknown. |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon7 TP53 D259N |
Transcript | NM_000546.6 |
gDNA | chr17:g.7674188C>T |
cDNA | c.775G>A |
Protein | p.D259N |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |