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Gene TP53
Variant A189D
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 A189D lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). A189D has been identified in sequencing studies (PMID: 23835706), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Dec 2023).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 A189D

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Transcript NM_000546.6
gDNA chr17:g.7674965G>T
cDNA c.566C>A
Protein p.A189D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407268.1 chr17:g.7674965G>T c.566C>A p.A189D RefSeq GRCh38/hg38
NM_000546 chr17:g.7674965G>T c.566C>A p.A189D RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674965G>T c.566C>A p.A189D RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674965G>T c.566C>A p.A189D RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674965G>T c.566C>A p.A189D RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674965G>T c.566C>A p.A189D RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674965G>T c.566C>A p.A189D RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674965G>T c.566C>A p.A189D RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674965G>T c.566C>A p.A189D RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674965G>T c.566C>A p.A189D RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674965G>T c.566C>A p.A189D RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674965G>T c.566C>A p.A189D RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674965G>T c.566C>A p.A189D RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674965G>T c.566C>A p.A189D RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674965G>T c.566C>A p.A189D RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674965G>T c.566C>A p.A189D RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674965G>T c.566C>A p.A189D RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References