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Gene | TP53 |
Variant | C124G |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | TP53 C124G lies within the DNA-binding domain of the Tp53 protein (PMID: 21760703). C124G has been identified in sequencing studies (Journal of Thoracic Oncology, Vol 13, Issue 10, S987-S988), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Jan 2025). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon4 TP53 C124G |
Transcript | NM_000546.6 |
gDNA | chr17:g.7675999A>C |
cDNA | c.370T>G |
Protein | p.C124G |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |