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Gene TP53
Variant F341V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 F341V lies within the tetramerization domain of the Tp53 protein (PMID: 20978130). F341V results in the inability to form Tp53 tetramers and decreased Tp53 transcriptional activity in yeast assays (PMID: 16007150), but has not been characterized in human cells and therefore, its effect on Tp53 function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon10 TP53 F341V

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Transcript NM_000546.6
gDNA chr17:g.7670688A>C
cDNA c.1021T>G
Protein p.F341V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407262.1 chr17:g.7670688A>C c.1021T>G p.F341V RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7670688A>C c.1021T>G p.F341V RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7670688A>C c.1021T>G p.F341V RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7670688A>C c.1021T>G p.F341V RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7673239A>C c.1021T>G p.F341V RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7670688A>C c.1021T>G p.F341V RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7670688A>C c.1021T>G p.F341V RefSeq GRCh38/hg38
NM_001126112 chr17:g.7670688A>C c.1021T>G p.F341V RefSeq GRCh38/hg38
NM_000546 chr17:g.7670688A>C c.1021T>G p.F341V RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7670688A>C c.1021T>G p.F341V RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7673239A>C c.1021T>G p.F341V RefSeq GRCh38/hg38
NM_001126113 chr17:g.7673239A>C c.1021T>G p.F341V RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References