Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Gene | TP53 |
Variant | R158C |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | TP53 R158C lies within the DNA-binding domain of the Tp53 protein (PMID: 21760703). R158C has been identified in the scientific literature (PMID: 25561229, PMID: 30766968, PMID: 9185695), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2024). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon5 TP53 R158C |
Transcript | NM_000546.6 |
gDNA | chr17:g.7675140G>A |
cDNA | c.472C>T |
Protein | p.R158C |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001126117 | chr17:g.7673752G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001407264.1 | chr17:g.7675140G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001407266.1 | chr17:g.7675140G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001126116.1 | chr17:g.7673752G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_000546.5 | chr17:g.7675140G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001126113.2 | chr17:g.7675140G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001126112 | chr17:g.7675140G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001126115.2 | chr17:g.7673752G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_000546.6 | chr17:g.7675140G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001126112.3 | chr17:g.7675140G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001126116.2 | chr17:g.7673752G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001126116 | chr17:g.7673752G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001126117.1 | chr17:g.7673752G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001126115 | chr17:g.7673752G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001126112.2 | chr17:g.7675140G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001126117.2 | chr17:g.7673752G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_000546 | chr17:g.7675140G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001407268.1 | chr17:g.7675140G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001407262.1 | chr17:g.7675140G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001126113.3 | chr17:g.7675140G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001126114 | chr17:g.7675140G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001126114.2 | chr17:g.7675140G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001126113 | chr17:g.7675140G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001126114.3 | chr17:g.7675140G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001126115.1 | chr17:g.7673752G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
NM_001407270.1 | chr17:g.7675140G>A | c.472C>T | p.R158C | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|