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Gene TP53
Variant K321E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 K321E lies within the HIPK1, CARM1 and HIPK2-interacting regions and the bipartite nuclear localization signal motif of the Tp53 protein (UniProt.org). K321E has not been characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon9 TP53 K321E

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Transcript NM_000546.6
gDNA chr17:g.7673567T>C
cDNA c.961A>G
Protein p.K321E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407268.1 chr17:g.7673567T>C c.961A>G p.K321E RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7673567T>C c.961A>G p.K321E RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7673567T>C c.961A>G p.K321E RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7673567T>C c.961A>G p.K321E RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7673567T>C c.961A>G p.K321E RefSeq GRCh38/hg38
NM_000546 chr17:g.7673567T>C c.961A>G p.K321E RefSeq GRCh38/hg38
NM_001126114 chr17:g.7673567T>C c.961A>G p.K321E RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7673567T>C c.961A>G p.K321E RefSeq GRCh38/hg38
NM_001126112 chr17:g.7673567T>C c.961A>G p.K321E RefSeq GRCh38/hg38
NM_001126113 chr17:g.7673567T>C c.961A>G p.K321E RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7673567T>C c.961A>G p.K321E RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7673567T>C c.961A>G p.K321E RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7673567T>C c.961A>G p.K321E RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7673567T>C c.961A>G p.K321E RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7673567T>C c.961A>G p.K321E RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7673567T>C c.961A>G p.K321E RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7673567T>C c.961A>G p.K321E RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References