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Gene TP53
Variant P12S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 P12S lies within the CCAR2 and HRMT1L2-interacting regions and the transcription activation region of the Tp53 protein (UniProt.org). P12S has been identified in sequencing studies (PMID: 29348365), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Dec 2023).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon2 TP53 P12S

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Transcript NM_000546.6
gDNA chr17:g.7676561G>A
cDNA c.34C>T
Protein p.P12S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407266.1 chr17:g.7676561G>A c.34C>T p.P12S RefSeq GRCh38/hg38
NM_001126113 chr17:g.7676561G>A c.34C>T p.P12S RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7676561G>A c.34C>T p.P12S RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7676561G>A c.34C>T p.P12S RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7676561G>A c.34C>T p.P12S RefSeq GRCh38/hg38
NM_001126112 chr17:g.7676561G>A c.34C>T p.P12S RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7676561G>A c.34C>T p.P12S RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7676561G>A c.34C>T p.P12S RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7676561G>A c.34C>T p.P12S RefSeq GRCh38/hg38
NM_001126114 chr17:g.7676561G>A c.34C>T p.P12S RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7676561G>A c.34C>T p.P12S RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7676561G>A c.34C>T p.P12S RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7676561G>A c.34C>T p.P12S RefSeq GRCh38/hg38
NM_000546 chr17:g.7676561G>A c.34C>T p.P12S RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7676561G>A c.34C>T p.P12S RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7676561G>A c.34C>T p.P12S RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7676561G>A c.34C>T p.P12S RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References