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Gene PIK3CA
Variant E453del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions PIK3CA E453del results in the deletion of an amino acid in the C2 PI3K-type domain of the Pik3ca protein at amino acid 453 (UniProt.org). E453del has been identified in sequencing studies (PMID: 35145232, PMID: 31349857, PMID: 26226847), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Nov 2023).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA E453del

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Transcript NM_006218.4
gDNA chr3:g.179210293_179210295delAGA
cDNA c.1359_1361delAGA
Protein p.E453del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218 chr3:g.179210293_179210295delAGA c.1359_1361delAGA p.E453del RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179210293_179210295delAGA c.1359_1361delAGA p.E453del RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179210293_179210295delAGA c.1359_1361delAGA p.E453del RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210293_179210295delAGA c.1359_1361delAGA p.E453del RefSeq GRCh38/hg38
XM_011512894 chr3:g.179210293_179210295delAGA c.1359_1361delAGA p.E453del RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210293_179210295delAGA c.1359_1361delAGA p.E453del RefSeq GRCh38/hg38
XM_006713658 chr3:g.179210293_179210295delAGA c.1359_1361delAGA p.E453del RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210293_179210295delAGA c.1359_1361delAGA p.E453del RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries